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Big Brain Holdings takes concentrated, long-term positions in conviction-driven, visionary founders, rooted in a cypherpunk ethos. The firm now invests across four areas: artificial intelligence (foundation models, inference infrastructure, AI-native and agentic systems), robotics (humanoid robots, autonomous systems, embodied AI), decentralized infrastructure (next-gen blockchain protocols, decentralized compute, Web3 primitives), and consumer and deep-tech at scale.
Hardware / software
Investment style
Generalist
Data last enriched
Aug 14, 2026
How to reach them
Notable investments
Solana, NEAR Protocol, Mysten Labs, Apptronik, Agility Robotics, Flashbots, Arweave, The Graph, Wormhole, Stacks